COVID-19 Antibody Assays

SARS-CoV-2 Neutralizing Antibody ELISA Kit:

Evaluation of immune response after COVID-19 vaccination and infection.

  • Quantitative, high throughput analysis for neutralizing antibodies in blood samples.
  • Particularly suitable for determining the neutralizing antibody titer after COVID-19 vaccination.
  • Neutralizing antibodies resulting from vaccination blocks the invasion of virus into host cells.
  • The ELISA specifically quantifies the neutralizing antibody titer of those antibodies, which will:
    • Block the receptor-binding domain (RBD) of the S1 subunit of virus’ Spike protein.
    • Thereby preventing the S1-RBD attachment to the human host cell ACE2 receptor.

  • This is achieved in a 1-step competitive ELISA based on:

    • ELISA-wells precoated with S1-RBD
    • Simultaneous competitive incubation of blood sample (antibodies) and peroxidase-labeled ACE-2

  • It takes little manual labor to analyze hundreds of samples in one run.

  • Clinically documented, 1-step RUO ELISA kit including all necessary reagents.

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1-step competitive ELISA

The Solsten SARS-CoV-2 Neutralizing Antibody ELISA Kit is a useful tool for quantifying the individual, time-dependent response to vaccination with COVID-19 vaccines from Pfizer-Biontech, Moderna, Astra Zeneca and Johnson&Johnson. Reference: Finalized study per January 11, 2022 at Solsten Diagnostics.

 

The Solsten SARS-CoV-2 Neutralizing Antibody ELISA is a 1-step competitive assay, where neutralizing antibodies in the blood sample competes with the peroxidase-labeled human ACE-2 receptor to bind to the immobilized receptor-binding domain of the virus’ Spike protein (S1-RBD). The reduction in color signal is proportional to the antibody-derived protection (titer) against the virus.

The Solsten SARS-CoV-2 Antibody Rapid Test Kit (Colloidal Gold Method):

The Solsten SARS-CoV-2 Antibody Rapid Test Kit (Colloidal Gold Method) is done in 10 minutes, and the signal for IgG and IgM antibodies against the virus is read easily by eye. Though the test is qualitative, the intensity of the IgG-band indicates the titer of the blood sample (according to ELISA quantification).

 

  • Easy-to-use Rapid Test for IgG and IgM antibodies reacting with antigens (N and S) of SARS-CoV-2.
  • Apply one drop of blood (fingerprick full blood or serum/plasma from venous blood sample).
  • Results in 10 minutes and qualitative reading by eye (pregnancy-test like output).
  • Clinically documented, CE-IVD marked Quick test kit for immediate use.
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The Solsten SARS-CoV-2 Antibody Rapid Test Kit (Fluorescence Method) and Reader Instrument:

The Solsten SARS-CoV-2 Antibody Rapid Test Kit (Fluorescence Method) is done in 15 minutes, and the titer of antibodies against the virus is measured by the BOH-180 Instrument.

  • Easy-to-use Quantitative Rapid Test for antibodies reacting with the receptor-binding domain (RBD) of the spike (S) protein of SARS-CoV-2.
  • Apply one drop of blood (fingerprick full blood or serum/plasma from venous blood sample).
  • Results in 15 minutes including quantitative reading in 20 seconds by Reader Instrument.
  • Clinically documented, RUO-IVD Quick test kit and Reader Instrument for immediate use.
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